tm4 sertoli cell line (ATCC)
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tm4 sertoli cell line
Tm4 Sertoli Cell Line, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 532 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/tm4+sertoli+cell+line/TM4/pm42314964-70-4-8
Average 96 stars, based on 532 article reviews
Tm4 Sertoli Cell Line, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 532 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/tm4+sertoli+cell+line/TM4/pm42314964-70-4-8
Average 96 stars, based on 532 article reviews
tm4 sertoli cell line - by Bioz Stars,
2026-09
96/100 stars
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Derivative Assay:Article Title: Development of a model for studying the developmental consequences of oxidative sperm DNA damage by targeting redox-cycling naphthoquinones to the Sertoli cell population. Article Snippet: .. Specifically, we used the Article Title: Melatonin improves oxidative state and lactate metabolism in rodent Sertoli cells. Article Snippet: Antioxidant actions of melatonin and its impact on testicular function and fertility have already been described.. Considering that Sertoli cells contribute to provide structural support and nutrition to germ cells, we evaluated the effect of melatonin on oxidative state and lactate metabolism in the immature murine TM4 cell line and in immature hamster Sertoli cells.. A prooxidant stimulus applied to rodent Sertoli cells expressing MT1/MT2 receptors, increased lipid peroxidation whereas decreased antioxidant enzymes (superoxide dismutase 1, catalase, peroxiredoxin 1) expression and catalase activity. Article Title: Reactive oxygen species (ROS) production triggered by prostaglandin D2 (PGD2) regulates lactate dehydrogenase (LDH) expression/activity in TM4 Sertoli cells. Article Snippet: Please cite this article as: Rossi, S.P., Windschuettl, S., Matzkin, M.E., Rey-Ares, V., Terradas, C., Ponzio, R., Puigdomenech, E., Levalle, O., Calandra, R.S., Mayerhofer, A., Frungieri, M.B., Reactive oxygen species (ROS) production triggered by prostaglandin D2 (PGD2) regulates lactate dehydrogenase (LDH) expression/activity in TM4 Sertoli cells, Molecular and Cellular Endocrinology (2016), doi: 10.1016/j.mce.2016.06.021. Article Title: Furan impairs cell function by inducing oxidative stress, DNA damage and apoptosis in mouse Sertoli cells in vitro . Article Snippet: Research on heat-induced food contaminants, such as furan, has shown its harmful effects on various systems. however, the impact of furan on sertoli cells, a crucial male reproductive system cell, has not been studied. the investigation involved the treatment of furan to tM4 sertoli cells at various concentrations (750, 1500, and 3000 μM) over a period of 24 h. this in vitro study determined that furan causes a decrease in sertoli cell viability and an increase in lactate dehydrogenase activity, leading to cytotoxicity. additionally, we observed an increase in MDa, one of the oxidative stress markers, in sertoli cells, indicating that furan exposure leads to lipid peroxidation. it was determined that enzyme activities in the antioxidant defense system in sertoli cells decreased after furan exposure. the findings indicate that furan induces oxidative damage in sertoli cells by impairing the activity of antioxidant enzymes and promoting the production of ROs. this study discovered that furan triggers apoptosis in sertoli cells by damaging DNa and altering the expression levels of apoptotic genes.. Moreover, results suggest that furan causes cellular toxicity and apoptosis, leading to damage to sertoli cells and thus causing male infertility. Cell Culture:Article Title: Oleanolic acid causes reversible contraception in male mice by increasing the permeability of the germinal epithelium Article Snippet: The effects of oleanolic acid (OA) on the fertility ofmalemicewere investigated using both in vivo and in vitro experimental models.. The experimental group (n1⁄4 12) was treated with a daily dose of 30 mgOA kg 1 bodyweight (i.p.), while the control group (n1⁄4 6) received a daily dose of 10%ethanol solution (1mLkg 1 bodyweight).. The effect of OAon the permeability status of TM4 Sertoli monolayers was investigated by measuring the transepithelial electrical resistance (TER), intracellular electrical resistance and semiquantitative RT–PCR. Article Title: Dose-dependent modulation of mitochondrial physiology and nutrient secretion in Sertoli cells by l-carnitine. Article Snippet: .. Cell Culture Conditions The Article Title: Reactive oxygen species (ROS) production triggered by prostaglandin D2 (PGD2) regulates lactate dehydrogenase (LDH) expression/activity in TM4 Sertoli cells. Article Snippet: Please cite this article as: Rossi, S.P., Windschuettl, S., Matzkin, M.E., Rey-Ares, V., Terradas, C., Ponzio, R., Puigdomenech, E., Levalle, O., Calandra, R.S., Mayerhofer, A., Frungieri, M.B., Reactive oxygen species (ROS) production triggered by prostaglandin D2 (PGD2) regulates lactate dehydrogenase (LDH) expression/activity in TM4 Sertoli cells, Molecular and Cellular Endocrinology (2016), doi: 10.1016/j.mce.2016.06.021. Article Title: Metabolomics and exploratory mendelian randomization identify indole-3-propionic acid associated with doxorubicin-induced testicular injury. Article Snippet: Doxorubicin (DOX) exhibits severe side effects that restrict its clinical application.. In the testes, DOX triggers apoptosis and excessive oxidative stress.. Modulation of the metabolic microenvironment may contribute to the amelioration of testicular injury. Isolation:Article Title: Furan impairs cell function by inducing oxidative stress, DNA damage and apoptosis in mouse Sertoli cells in vitro . Article Snippet: Research on heat-induced food contaminants, such as furan, has shown its harmful effects on various systems. however, the impact of furan on sertoli cells, a crucial male reproductive system cell, has not been studied. the investigation involved the treatment of furan to tM4 sertoli cells at various concentrations (750, 1500, and 3000 μM) over a period of 24 h. this in vitro study determined that furan causes a decrease in sertoli cell viability and an increase in lactate dehydrogenase activity, leading to cytotoxicity. additionally, we observed an increase in MDa, one of the oxidative stress markers, in sertoli cells, indicating that furan exposure leads to lipid peroxidation. it was determined that enzyme activities in the antioxidant defense system in sertoli cells decreased after furan exposure. the findings indicate that furan induces oxidative damage in sertoli cells by impairing the activity of antioxidant enzymes and promoting the production of ROs. this study discovered that furan triggers apoptosis in sertoli cells by damaging DNa and altering the expression levels of apoptotic genes.. Moreover, results suggest that furan causes cellular toxicity and apoptosis, leading to damage to sertoli cells and thus causing male infertility. In Vitro:Article Title: Furan impairs cell function by inducing oxidative stress, DNA damage and apoptosis in mouse Sertoli cells in vitro . Article Snippet: Research on heat-induced food contaminants, such as furan, has shown its harmful effects on various systems. however, the impact of furan on sertoli cells, a crucial male reproductive system cell, has not been studied. the investigation involved the treatment of furan to tM4 sertoli cells at various concentrations (750, 1500, and 3000 μM) over a period of 24 h. this in vitro study determined that furan causes a decrease in sertoli cell viability and an increase in lactate dehydrogenase activity, leading to cytotoxicity. additionally, we observed an increase in MDa, one of the oxidative stress markers, in sertoli cells, indicating that furan exposure leads to lipid peroxidation. it was determined that enzyme activities in the antioxidant defense system in sertoli cells decreased after furan exposure. the findings indicate that furan induces oxidative damage in sertoli cells by impairing the activity of antioxidant enzymes and promoting the production of ROs. this study discovered that furan triggers apoptosis in sertoli cells by damaging DNa and altering the expression levels of apoptotic genes.. Moreover, results suggest that furan causes cellular toxicity and apoptosis, leading to damage to sertoli cells and thus causing male infertility. Modification:Article Title: Furan impairs cell function by inducing oxidative stress, DNA damage and apoptosis in mouse Sertoli cells in vitro . Article Snippet: Research on heat-induced food contaminants, such as furan, has shown its harmful effects on various systems. however, the impact of furan on sertoli cells, a crucial male reproductive system cell, has not been studied. the investigation involved the treatment of furan to tM4 sertoli cells at various concentrations (750, 1500, and 3000 μM) over a period of 24 h. this in vitro study determined that furan causes a decrease in sertoli cell viability and an increase in lactate dehydrogenase activity, leading to cytotoxicity. additionally, we observed an increase in MDa, one of the oxidative stress markers, in sertoli cells, indicating that furan exposure leads to lipid peroxidation. it was determined that enzyme activities in the antioxidant defense system in sertoli cells decreased after furan exposure. the findings indicate that furan induces oxidative damage in sertoli cells by impairing the activity of antioxidant enzymes and promoting the production of ROs. this study discovered that furan triggers apoptosis in sertoli cells by damaging DNa and altering the expression levels of apoptotic genes.. Moreover, results suggest that furan causes cellular toxicity and apoptosis, leading to damage to sertoli cells and thus causing male infertility. Incubation:Article Title: Furan impairs cell function by inducing oxidative stress, DNA damage and apoptosis in mouse Sertoli cells in vitro . Article Snippet: Research on heat-induced food contaminants, such as furan, has shown its harmful effects on various systems. however, the impact of furan on sertoli cells, a crucial male reproductive system cell, has not been studied. the investigation involved the treatment of furan to tM4 sertoli cells at various concentrations (750, 1500, and 3000 μM) over a period of 24 h. this in vitro study determined that furan causes a decrease in sertoli cell viability and an increase in lactate dehydrogenase activity, leading to cytotoxicity. additionally, we observed an increase in MDa, one of the oxidative stress markers, in sertoli cells, indicating that furan exposure leads to lipid peroxidation. it was determined that enzyme activities in the antioxidant defense system in sertoli cells decreased after furan exposure. the findings indicate that furan induces oxidative damage in sertoli cells by impairing the activity of antioxidant enzymes and promoting the production of ROs. this study discovered that furan triggers apoptosis in sertoli cells by damaging DNa and altering the expression levels of apoptotic genes.. Moreover, results suggest that furan causes cellular toxicity and apoptosis, leading to damage to sertoli cells and thus causing male infertility. In Vivo:Article Title: Furan impairs cell function by inducing oxidative stress, DNA damage and apoptosis in mouse Sertoli cells in vitro . Article Snippet: Research on heat-induced food contaminants, such as furan, has shown its harmful effects on various systems. however, the impact of furan on sertoli cells, a crucial male reproductive system cell, has not been studied. the investigation involved the treatment of furan to tM4 sertoli cells at various concentrations (750, 1500, and 3000 μM) over a period of 24 h. this in vitro study determined that furan causes a decrease in sertoli cell viability and an increase in lactate dehydrogenase activity, leading to cytotoxicity. additionally, we observed an increase in MDa, one of the oxidative stress markers, in sertoli cells, indicating that furan exposure leads to lipid peroxidation. it was determined that enzyme activities in the antioxidant defense system in sertoli cells decreased after furan exposure. the findings indicate that furan induces oxidative damage in sertoli cells by impairing the activity of antioxidant enzymes and promoting the production of ROs. this study discovered that furan triggers apoptosis in sertoli cells by damaging DNa and altering the expression levels of apoptotic genes.. Moreover, results suggest that furan causes cellular toxicity and apoptosis, leading to damage to sertoli cells and thus causing male infertility. Control:Article Title: Furan impairs cell function by inducing oxidative stress, DNA damage and apoptosis in mouse Sertoli cells in vitro . Article Snippet: Research on heat-induced food contaminants, such as furan, has shown its harmful effects on various systems. however, the impact of furan on sertoli cells, a crucial male reproductive system cell, has not been studied. the investigation involved the treatment of furan to tM4 sertoli cells at various concentrations (750, 1500, and 3000 μM) over a period of 24 h. this in vitro study determined that furan causes a decrease in sertoli cell viability and an increase in lactate dehydrogenase activity, leading to cytotoxicity. additionally, we observed an increase in MDa, one of the oxidative stress markers, in sertoli cells, indicating that furan exposure leads to lipid peroxidation. it was determined that enzyme activities in the antioxidant defense system in sertoli cells decreased after furan exposure. the findings indicate that furan induces oxidative damage in sertoli cells by impairing the activity of antioxidant enzymes and promoting the production of ROs. this study discovered that furan triggers apoptosis in sertoli cells by damaging DNa and altering the expression levels of apoptotic genes.. Moreover, results suggest that furan causes cellular toxicity and apoptosis, leading to damage to sertoli cells and thus causing male infertility. |
![Fluoride impairs male reproductive capacity by differentially regulating autophagy of testicular somatic cells in mice. (A to F) Six-week-old male mice freely drank distilled water with or without 100 mg/l NaF for 18 weeks. (A) Representative images of H&E staining on testis. Scale bars, 100 μm (left) and 50 μm (right). (B) Representative microscopic views of sperm morphology. Scale bars, 50 μm. (C) Sperm quality. (D and E) Representative transmission electron microscopy images of autophagosomes in (D) Leydig cells and (E) Sertoli cells [scale bars, 2 μm (bottom) and 1 μm (top)], with red arrows indicating autophagosomes. (F) Immunohistochemistry was used to detect the protein expression of LC3B and p62 in Leydig cells and Sertoli cells. (G and H) Testicular somatic cells were treated with various concentrations of NaF for 24 h. The relative expression of LC3B and p62 proteins in (G) TM3 cells, (H) <t>TM4</t> cells, and (I) TM4 cells cotreated with 20 μM chloroquine. Cell viability of (J) TM3 and (K) TM4 cells that were treated with 0.25 mM NaF and 20 μM chloroquine for 24 h or pretreated with 20 nM rapamycin for 1 h. All values in the figure are means ± SEM. n ≥ 3. * P < 0.05, ** P < 0.01 versus control; # P < 0.05, ## P < 0.01 versus chloroquine.](https://pub-med-central-images-cdn.bioz.com/pub_med_central_ids_ending_with_7340/pmc12877340/pmc12877340__research.1113.fig.001.jpg)
